Date:-Day II, Friday 6th Oct. 2017, 9:30 to 17:00 hrs.
Venue:- Crystal Ballroom – 1, Ramada Powai, Hotel & Convention Centre, Mumbai.

IGCW – ACS – GCI PHARMA ROUNDTABLE WORKSHOP ON SOLVENT & REAGENT SELECTION TOOLS & TECHNIQUES TO DRIVE GREEN & SUSTAINABLE CHEMISTRY


The one day work-shop will enhance your sustainability performance in developing and manufacturing Active Pharmaceutical Ingredients (APIs) and intermediates using green chemistry and engineering techniques honed over 11 years by leading pharmaceutical companies.

The ACS GCI Pharmaceutical Roundtable member companies have combined and leveraged their experience and expertise using Green and Sustainable chemistry and engineering principles and techniques and developed many tools like the solvent selection guide, the reagent selection guide and the Process Mass Intensity (PMI) calculator to name some of them.

In this one day workshop the participants will learn how to design a greener route, select the most appropriate reagents and solvents to minimize waste and maximize safety, choose sustainability metrics that make sense to monitor your progress toward greener manufacturing, and discover other technologies for streamlined synthetic approaches.

The ACS GCI Pharmaceutical Roundtable has performed several PMI benchmarking exercises of chemical processes across the different development stages over the last decade within the member companies and they all showed consistently that about 58% of the waste comes from solvents, about 28 % from water and about 8% from raw materials. Therefore smarter decisions on solvents (including water) and raw materials using a solvent and reagent selection guide will result quickly in significant reductions of waste and enhance greener and more sustainable processing quickly.

The workshop will give a brief overview about the history of Green and Sustainable Chemistry, an introduction to the different metrics to enable the monitoring of success toward Green Chemistry, introduce the concept to making smarter decisions on solvents and reagents by applying selection guides, discuss flow chemistry as a potential greener option for certain reactions  and finally will discuss examples of successful greener process developments within the ACS GCI PRT member companies to illustrate the importance of key elements to drive and develop greener and more sustainable processes. 

At the end of the workshop, the participant will understand the importance of preventing waste instead of treating it after creation, the use of metrics to identify the areas of greatest need and opportunities to streamline chemical routes, to identify sustainable alternatives regarding solvents and reagent choices to limit waste, to create a safer work environment and provide cost savings. Finally the attendees will better understand how to minimize (hazardous) materials and streamline construction of complex molecules in a more sustainable and greener way. Throughout the course interactive exercises will familiarize the attendees with the concepts of Green and Sustainable Chemistry and will show the benefits and wins when applied in practice. Green chemistry is a triple win: cost effective, better for the environment and safer for the employees.

Participation focus - chief representatives from R&D, R&T, production, operations and environmental health and safety sectors

Tentative Agenda

Introduction to GC&E metrics
Brief overview of different metrics – exercise (application of metrics)
Green Chemistry tools
  • Solvent Guide
  • Reagent guide
  • PMI calculator
Solvent alternatives for routine synthetic operations within labs
  • Replacement of methylene chloride for chromatography
  • Replacing DCM and DMF in amidation and amination reactions
  • Reactions in water using surfactants
Reactions
  • Case studies – original synthesis and greener /more sustainable version – drivers for change
  • Sustainable metals – replacement of precious metals
  • Continuous flow – type of flow reactors and application
  • Nanofiltration instead of distillation
Green Chemistry in the literature
Outlook - Bringing it all together
  • Financial value of Green Chemistry